CAS No.: | 1270138-41-4 |
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Formula: | C22h33n4o5p |
EINECS: | Nsi-189 Phosphate |
Type: | Pharmaceutical Intermediates |
Appearance: | Powder |
Quality: | Industrial |
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Customization: |
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Detailed Product Information
Product Name: NSI-189 Phosphate
Trade Name: NSA-189
CAS No.: 1270138-41-4
Molecular Formula: C22H33N4O5P
Molecular Weight: 464.503g/mol
Purity: 99% HPLC
Appearance: White Powder
Typical use: Antidepressants
Standard Packing: 100gram,1kg,25kg
Shelf Life: 2 years
Storage: Room temperature away from light
Description:
NSI-189 is a benzylpiperizine-aminiopyridine, a novel chemical entity that stimulates neurogenesis of human hippocampus-derived neural stem cells in vitro and stimulates neurogenesis in murine hippocampus in vivo. Emerging evidence also indicates that NSI-189 phosphate has regionally specific effects insofar as neurogenesis is observed largely in the subventricular zone of the hippocampus. Results from a preliminary proof of concept study suggests that NSI-189 may be capable of mitigating depressive symptoms and improve cognitive function in adults with DSM-5-defined Major Depressive Disorder (MDD).
NSI-189 is a new investigational antidepressant, which is purported to work differently from existing antidepressants. Researchers suggest this drug may potentially help those who do not respond to conventional medications. Research is also ongoing for its cognitive-enhancing effects. However, NSI-189 failed in a recent clinical trial. Learn about all the research behind this drug.
NSI-189 Freebase vs. Phosphate Powder: What's the Difference?
There are instances when both freebase and phosphate are available, and users get confused about which one to get.
Both forms benefit from improving depressive symptoms while showing better cognitive function.
Here is what you should know about their difference to add some clarity.
Phosphate is the one used by Neuralstem Inc in their clinical trials. It is best taken orally and is about 15 to 20% more expensive than the other version but is much more stable and has better bioavailability.
The freebase version is used for sublingual ROA. It is the secondary amine, the nitrogen atom bonded to two carbon atoms and one hydrogen atom. It has poor bioavailability.
If you consider purchasing NSI 189, you may want to consider the mentioned factors to know whether to get the free base or the phosphate.
Product Benefits:
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